Novel small-molecule MRGPRX2 antagonists inhibit the murine model of allergic reactions

By Eric Lee
Jan 19th 2023

Latest publication by Prof. Billy Chow and Dr Chi Bun CHAN labs

Activation of Mas-related G protein-coupled receptor X2 (MRGPRX2) is a crucial non-IgE pathway for mast cell activation associated with allergic reactions and inflammation. Only a few peptides and small compounds targeting MRGPRX2 have been reported, with limited information on their pharmacological activity.

They sought to develop novel small molecule MRGPRX2 antagonists to treat MRGPRX2 mediated allergies and inflammation.

The small molecules might hold a significant therapeutic promise to treat MRGPRX2 mediated allergies and inflammation

The journal paper can be accessed here: