Decoding a new sign in chromatin maze: HKU chemical biologists identify a new histone mark that regulates chromatin structure during gene expression and DNA repair

By Eric Lee
Oct 08th 2019

A research team led by Dr Xiang David Li, Associate Professor from the Department of Chemistry, in collaboration with Dr Karen Wing Yee Yuen from the School of Biological Sciences and Dr Jason Wing Hon Wong from the School of Biomedical Sciences at The University of Hong Kong (HKU), revealed a new fundamental mechanism by which a cell can make necessary changes in its chromatin structure in response to different DNA-associated processes such as gene expression and DNA damage repair. The findings were recently published in the prestigious scientific journal Molecular Cell.

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The paper “Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics” at ‘Molecular Cell’, please visit: