Awards:
| 2010 | HKU Outstanding Young Researcher Award (HKU OYRA) |
| 2008 | Who's Who in Science and Engineering |
| 2002 | SSR Ewing Travel Award, Society for the Study of Reproduction, USA |
| 2002 | Best Oral Presentation Award, First Asia-Pacific Forum on Andrology, Shanghai |
| 2001-2002 | Hong Kong Association of University Women Thomas HC Cheung Award |
| 2001 | Predoctoral Student Travel Award, American Society for Cell Biology, USA |
| 1999-2001 | Sir Edward Youde Fellowship, Hong Kong |
Current Research:
Molecular Endocrinology and Reproduction
Cytokine-mediated regulation of cell junction restructuring during spermatogenesis
Transcriptional, post-transcriptional and post-translational regulation of junction proteins
Role and regulation of E3 ligase (ITCH) in the testis
Ubiquitin-dependent protein degradation in the testis
Teaching:
| BIOL0126 | Fundamentals of Biology (Coordinator) |
| BIOL1133 | Biological Sciences Laboratory Course (Coordinator) |
| BIOL2115 | Cell Biology & Cell Technology |
| BIOL2215 | Animal Physiology |
| BIOL2218 | Human Physiology (Coordinator) |
| BIOL3212 | Clinical Microbiology and Applied Immunology (Coordinator) |
Publications:
Li MWM, Lee WM, Lui WY* (2011) Expression of Itch in Sertoli cells is controlled via the interaction of E2F1/DP1 complex with E2F and GATA motifs. Spermatogenesis (in press)
Cheng CY, Wong EWP, Lie PPY, Mruk DD, Xiao X, Li MWM, Lui WY, Lee WM (2011) Polarity proteins and actin regulatory proteins are unlikely that regulate cell adhesion in the seminiferous epithelium during spermatogenesis. Histol Histopathol 26:1465-1475 pubmed abstract
Mok KW, Mruk DD, Lie PPY, Lui WY, Cheng CY* (2011) Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes. Reproduction 141:571-580 pubmed abstract
Li MWM, Xiao X, Mruk DD, Lam YL, Lee WM, Lui WY, Bonanomi M, Silvestrini B, Cheng CY* (2011) Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis. Spermatogenesis (in press)
Lui WY* and Cheng CY (2011) Transcriptional regulation of cell adhesion at the blood-testis barrier and spermatogenesis in the testis. In Biology and Regulation of Blood-Tissue Barriers, Ed: CY Cheng. Austin, TX, USA: Landes Bioscience and Springer Science. (in press)
Cheng CY, Wong EWP, Lie PPY, Li MWM, Mruk DD, Yan HH, Mok KW, Mannu J, Mathur PP, Lui WY, Lee WM, Bonanomi M, Silvestrini B (2011) Regulation of blood-testis barrier dynamics by desmosome, gap junction, hemidesmosome, and polarity proteins – an unexpected turn of events. Spermatogenesis (in press)
Wang Y and Lui WY* (2009) Opposite effects of interleukin-1a (IL-1a) and transforming growth factor-b2 (TGF-b2) induce stage-specific regulation of junctional adhesion molecule-B (JAM-B) gene in Sertoli cells. Endocrinology 150:2404-2412 pubmed abstract
Lui WY and Lee WM* (2009) Molecular mechanisms by which hormones and cytokines regulate male reproductive functions. Journal of Molecular Endocrinology 43:43-51. Invited. pubmed abstract
Sze KL and Lui WY* (2008) Transcriptional and post-transcriptional regulation of cell junction proteins in mammalian testis. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 8:95-102 Invited
Sze KL, Lee WM, Lui WY* (2008) Expression of CLMP, a novel tight junction protein, is mediated via the interaction of GATA with the Kruppel Family proteins, KLF4 and Sp1, in mouse testis. Journal of Cellular Physiology 214:334-344 pubmed abstract
Lui WY* and Cheng CY (2008) Transcription regulation in spermatogenesis. In Molecular Mechanisms in Spermatogenesis, p.115-132. Ed: CY Cheng.Austin, TX, USA: Landes Bioscience. pubmed abstract
Lui WY and Lee WM* (2008) Mechanisms of reorganization of intercellular junctions in the testis. Frontiers in Bioscience 13:6775-6786 Invited pubmed abstract
Sze KL, Lui WY, Lee WM* (2008) Post-transcriptional regulation of CLMP mRNA is controlled by Tristetraprolin in response to TNFa via c-Jun N-terminal kinase signaling. Biochemical Journal 410:575-583 pubmed abstract
Lui WY* and Lee WM (2008) Ubiquitin system in male reproduction and its relevance to contraception. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 8:14-19 Invited
Lui WY* and Cheng CY (2007) Regulation of cell junction dynamics by cytokines in the testis – a molecular and biochemical perspective. Cytokine & Growth Factor Reviews 18:299-311 pubmed abstract
Lui WY, Wong EW, Guan Y, Lee WM* (2007) Dual transcriptional control of claudin-11 via an overlapping GATA/NF-Y motif: Positive regulation through the interaction of GATA, NF-YA and CREB and negative regulation through the interaction of Smad, HDAC1 and mSin3A. Journal of Cellular Physiology 211:638-648 pubmed abstract
Lui WY, Sze KL, Lee WM* (2006) Nectin-2 expression in testicular cells is controlled via the functional cooperation between transcription factors of the Sp1, CREB, and AP-1 families. Journal of Cellular Physiology 207:144-157 pubmed abstract
Lui WY and Lee WM* (2006) Regulation of junction dynamics in the testis – Transcriptional and post-translational regulations of cell junction proteins. Molecular and Cellular Endocrinology 250:25-35 pubmed abstract
Li MW, Xia W, Mruk D, Wang CQ, Yan HH, Siu MK, Lui WY, Lee WM, Cheng CY* (2006) Tumor necrosis factor a reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testis. Journal of Endocrinology 190:313-329 pubmed abstract
Lui WY and Lee WM* (2005) cAMP perturbs inter-Sertoli tight junction permeability barrier in vitro via its effect on proteasome-sensitive ubiquitination of occludin. Journal of Cellular Physiology 203:564-572 pubmed abstract
Lui WY, Mruk DD, Lee WM, Cheng CY* (2005) Interactions among IQGAP1, cdc42, and the cadherin/catenin protein complex regulate Sertoli-germ cell adherens junction dynamics in the testis. Journal of Cellular Physiology 202:49-66 pubmed abstract
Lui WY, Cheng YH, Mruk DD, Cheng CH, Mo MY, Lee WM, Cheng CY* (2005) a2-Macroglobulin expression in the liver in response to inflammation is mediated by the testis. Journal of Endocrinology 185:497-505 pubmed abstract
Cheng CY, Mruk D, Silvestrini B, Bonanomi M, Wong CH, Siu MK, Lee NP, Lui WY, Mo MY (2005) AF-2364 [1-(2,4-dichlorobenzyl)-indazole-3-carbohydrazide] is a potential male contraceptive in adult rats: A review of recent data. Contraception 72:251-261 pubmed abstract
Wong CH, Mruk DD, Lui WY, Cheng CY* (2004) Regulation of the blood-testis barrier dynamics in the testis: an in vivo study. Journal of Cell Science 117:783-798 [Highlighted article in that issue] pubmed abstract
Lui WY, Wong CH, Mruk DD, Cheng CY* (2003) TGF-b3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: An in vivo study. Endocrinology 144:1139-1142 pubmed abstract
Lui WY, Mruk D, Lee WM, Cheng CY* (2003) Sertoli cell tight junction dynamics: Their regulation during spermatogenesis. Biology of Reproduction 68:1087-1097 pubmed abstract
Lui WY, Lee WM, Cheng CY* (2003) Rho GTPases and spermatogenesis. Biochimica et Biophysica Acta-Molecular Cell Research 1593:121-129 pubmed abstract
Lui WY, Lee WM, Cheng CY* (2003) Transforming growth factor-b3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway. Biology of Reproduction 68:1597-1612 pubmed abstract
Lui WY, Lee WM, Cheng CY* (2003) Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway. Biology of Reproduction 68:2189-2206 pubmed abstract
Lui WY, Mruk D, Lee WM, Cheng CY* (2003) Adherens junction dynamics in the testis and spermatogenesis. Journal of Andrology 24:1-14 pubmed abstract
Lui WY, Lee WM, Cheng CY* (2003) TGF-bs: Their role in testicular function and Sertoli cell tight junction dynamics. International Journal of Andrology 26:1-14 pubmed abstract
Lui WY, Lee WM, Cheng CY* (2001) Transforming growth factor-b3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11. Endocrinology 142:1865-1877 pubmed abstract
Wong AS, Lui WY, Hui IT, Lee WM* (2001) Rabbit sex hormone-binding globulin: Expression in the liver and testis during postnatal development and structural characterization by truncated proteins. International Journal of Andrology 24:165-174 pubmed abstract
People
Current Members:
Heidi Kong (Technician)
Wang Yang
Gao Ying
Zhang Xu
Patrick Chan Ka Wai
Chloe Lam Hang Yee
Kanry Gan
Graduates and alumni:
Sze Kit Ling [PhD]
Wang Yang [MPhil]
Richie Leung Tsz Ki [MPhil]
Rachel Tam Chun Yee [MPhil]
Gavin Poon Ka Ming [BSc]
Lab Photos:
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