Research Interests:

  • Lipid peroxidation and profiling of biological samples.
  • Development and measurement of oxidative damage biomarkers in biological samples using GC/MS and LC-MS/MS.
  • Oxidative stress and disease development.
  • Antioxidant and oxidative stress in human nutrition.
  • Oxidative stress and environmental stressors.

Teaching

Undergraduate
  • Food & Nutritional Science Major Curriculum Coordinator
  • Food & Nutritional Science Major Capstone Course Coordinator
Courses
BIOL 2101 Food Chemistry
BIOL 3209 Food & Nutrient Analysis Laboratory Course
BIOL 4208 Meat, Dairy & Grain Sciences
   
BIOL 4913 Advanced Practicum on Food & Nutrient Analysis
BIOL 4962 Food & Nutritional Science Internship
CCST 9052 Coffee, Cigarettes, and Alcohol
Postgraduate
Courses
BIOL 6001 Presentation Skills and Research Seminars in Biological Sciences: Food & Nutritional Science Module Coordinator
BIOL8020 Special Topics in Food & Nutritional Science

Academic Appointments

2003-2011 Research Fellow
National University of Singapore
Yong Yoo Lin School of Medicine
Department of Biochemistry/Medicine
Neurobiology/Aging Programme
 
2002-2003 Research Assistant Professor
Korea University 
Graduate School of Biotechnology
Food & Biomaterial Science & Engineering Laboratory
 
1999-2001 Post-Doctoral Research Associate
Korea University
Graduate School of Biotechnology
Food & Biomaterial Science & Engineering Laboratory
 

Awards

2014 University of Montpellier 1, Faculty of Pharmacy, Visiting Professorship Award
2014 HKU Overseas Fellowship Awards
1997 Award of High Standard of Presentation at  the Society for the Study of Endocrinology Metabolism and Reproduction (Hong Kong). XIth Annual Scientific Meeting.

Current Research Projects

2014-present Oxylipins and cardioprotection
2014-present Lipid mediators and plant polyunsaturated fatty acids
2015-present Age-macular degeneration and dietary oil
2016-present Lipophenols and disease protection
2016-present Lipid mediators and environmental stressors

Committee Member

  • Hong Kong Food Science & Technology Association
  • Hong Kong Nutrition Association
  • Institute of Food Technologists, USA
  • Hong Kong Flow Cytometry Society
  • Korean Society of Food Science and Technology
  • Korean Society of Food and Nutritional Science
  • Oxidant and Antioxidant Research Group, National University Singapore
  • Society for Free Radical Biology & Medicine

Current Collaborators:

  • Dr. Thierry Durand Directeur de Recherche Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - Universités Montpellier France 
  • Dr. Jean-Marie Galano Chargé de Recherche CNRS, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - Universités Montpellier, France

Publications:

Year 2011-Current:
  • Galano JM, Lee YY, Oger C, Vigor C, Vercauteren J, Durand T, Giera M, Lee JCY* (2017). Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology. Progress in Lipid Research 68:83-108.

  • Poon WL, Alenius H, Ndika J, Fortino V, Kolheinen V, Meščeriakovas A, Wang M, Greco D, Lähde A, Jokiniemi J, Lee JCY, El-Hezami H, Karisola P (2017). Nano-sized zinc oxide and silver, but not titanium dioxide, induce innate and adaptive immunity and antiviral response in differentiated THP-1 cells. Nanotoxicology DOI: 10.1080/17435390.2017.1382600

  • Lai KP*, Lee JCY*, Wan HT, Li JW, Wong AY, Chan TF, Oger C, Galano JM, Durand T, Leung KS, Leung CC, Li R, Wong CK (2017). Effects of in utero PFOS exposure on transcriptome, lipidome and function of mouse testis. Environmental Science & Technology 51:8782-8794.

  • Roy J, Galano JM, Durand T, Le Guennec JY, Lee JCY* (2017). Physiological role of reactive oxygen species as promoters of natural defences. FASEB Journal 31:3729-3745.
  • Cuyamendous C, Leung KS, Bultel-Poncé V, Guy A, Durand T, Galano JM*, Lee JCY*, Oger C (2017). Total syntheses and in vivo quantitation of novel Phytofurans derived from a-linolenic acid. European Journal of Organic Chemistry 2486-2490.

  • Demion M, Oger C, Vigor C, Thireau J, Le Guennec JY, Durand T, Galano JM, Lee JCY* (2017). Two sides of the same coin: NEO-PUFAs in Rett syndrome and post-infarction cardiac arrhythmias. European Journal of Lipid Science and Technology 119:1600320.

  •  Leung KS, Chan HF, Leung HH, Galano JM, Oger C, Durand T, Lee JCY* (2017). Short-time UVA exposure to human keratinocytes instigated polyunsaturated fatty acid without inducing lipid peroxidation. Free Radical Research 51: 269-280.

  • Roy J, Fauconnier J, Oger C, Farah C, Angebault-Prouteau C, Thireau J, Bideaux P, Scheuermann V, Bultel-Poncé V, Demion M, Galano JM, Durand T, Lee JCY*, Le Guennec JY* (2017). Non-enzymatic oxidized metabolite of DHA, 4(RS)-4-F4t-neuroprostane protects the heart against reperfusion injury. Free Radical Biology & Medicine 102: 229-239.

  • Lee YY, Crauste C, Wang H, Leung HH, Vercauteren J, Galano JM, Oger C, Durand T, Wan JMF, Lee JCY* (2016). Extra virgin olive oil reduced polyunsaturated fatty acid and cholesterol oxidation in rodent liver: Is this accounted for hydroxytyrosol-fatty acid conjugation? Chemical Research in Toxicology 29:1689-1698.

  • Lee YY, Galano JM, Oger C, Vigor C, Guillaume, Roy J, Le Guennec JY, Durand T, Lee JCY* (2016). Assessment of isoprostanes in human plasma: Technical considerations and the use of mass spectrometry. Lipids 51:1217-1229.

  • Dupuy A, Le Faouder P, Vigor C, Oger C, Galano JM, Dray C, Lee JCY, Valet P, Gladine C, Durand T, Bertrand-Michel J (2016). Simultaneous quantitative profiling of 20 isoprostanoids from omega-3 and omega-6 polyunsaturated fatty acids by LC-MS/MS in various biological samples. Analytica Chimica Acta 921:46-58.

  • Mok A, Haldar S, Lee JCY, Leow MKS, Henry CJ (2016). Postprandial changes in cardiometabolic disease risk in young Chinese men following isocaloric high or low protein diets, stratified by either high or low meal frequency - a randomized controlled crossover trial. Nutrition Journal 15:27

  • Roy J, Le Guennec JY, Glano JM, Thireau J, Bultel-Ponce V, Demion M, Oger C, Lee JCY, Durand T (2016). Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs? Biochimie 120:56-61.

  • Cyuamendous C, Leung KS, Durand T, Lee JCY*, Oger C*, Galano G* (2015) Synthesis and discovery of phytofurans: metabolites of α-linolenic acid peroxidation. Chemistry Communication 51:15696-15699

  • Leung KS, Galano JM, Durand T, Lee JCY* (2015) Current development in non-enzymatic lipid peroxidation products, isoprostanoids and isofuranoids in novel biological samples. Free Radical Research 49:816-826

  • Roy J, Oger, C, Thireau J, Roussel J, Mercier-Touzet O, Delinger F, Pinot E, Farah C, Taber DF, Cristol JP, Lee JCY, Lacampagne A, Galano JM, Durand T, Le Guennec JY (2015) Non-enzymatic lipid mediators, neuropros- tanes, exert the anti-arrhythmic properties of docosahexaenoic acid. Free Radical Biology & Medicine 86:269-278.

  • Yiu EM, Tai G, Peverill RE, Lee KJ, Croft K, Mori TA, Scheiber-Mojdehka B, Sturm B, Praschberger M, Vogel AP, Rance G, Stephenson SEM, Sarsero JP, Stockley C, Lee CYJ, Chrurchyard A, Evans-Galea MV, Ryan MM, Lockhart PJ, Corben LA, Delatycki MB (2015) An open-label trial in Friedreich ataxia suggests clinical benefit with high-dose resveratrol, without effect on frataxin levels. Journal of Neurology 262:1344-1353.

  • Lee YY, Wong CK, Oger C, Durand T, Galano JM, Lee JCY* (2015) Prenatal exposure of the contaminant perfluorooctane sulfonate elevates lipid peroxidation during mouse fetal development but not the pregnant dam. Free Radical Research 49:1015-1025. 

  • Chung ML, Galano JM, Oger C, Durand T, Lee JCY* (2015) Hyperoxia elevates adrenic acid peroxidation in marine fish and is associated with reproductive pheromone mediators. Marine Drugs 13:2215-2232.

  • Galano JM, Lee YY, Durand T, Lee JCY* (2015) The use of isoprostanoids as biomarkers of oxidative damage, and their role in human dietary intervention studies. Free Radical Research 49:583-598.

  • De La Torre A, Lee YY, Massoni A, Guy A, Bultel-Ponce V, Durand T, Oger C*, Lee JCY*, Galano JM* (2015) Total syntheses and in vivo quantitation of novel neurofuran and dihomo-isofuran derived from docosahexaenoic acid and adrenic acid. Chemistry A European Journal 21: 2442-2446.

  • Wang H, Zhang J, Sit WH, Lee CYJ, Wan JMF (2014) Cordyceps cicadae induces G2/M cell cycle arrest in MHCC97H human hepatocellular carcinoma cells: a proteomic study. Chinese Medicine 9:15

  • Galano JM, Lee JCY, Gladine C, Comte B, Le Guennec JY, Oger C, Durand T (2014) Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and α-linolenic acids; bioactivities and potential use as biomarkers. Biochimica et Biphysica Acta 1851:446-455.

  • De La Torre A, Lee YY, Oger C, Sangild PT, Durand T, Lee JCY*, Galano JM*. (2014) Synthesis, discovery and quantitation of dihomo-Isofurans: Novel biomarkers of in vivo adrenic acid peroxidation. Angewandte Chemie International Edition 53: 6249-6252.

  • Vigor C, Bertrand-Michel J, Pinot E, Oger C, Vercauteren J, Le Faouder P, Galano JM, Lee JCY*, Durand T* (2014) Non-enzymatic lipid oxidation products in biological systems: Assessment of the metabolites from polyunsaturated fatty acids. Journal of Chromatography 964:65-78.

  • Ng MPE, Lee JCY, Loke WM, Yeo LLL, Quek AML, Lim ECH, Halliwell B, Seet RCS. (2014) Does influenza A infection increase oxidative damage? Antioxidant & Redox Signaling 21:1025-1031.

  • Leung KS, Chen X, Zhong W, Yu ACH, Lee CYJ* (2014) Microbubble-mediated sonoporation amplified lipid peroxidation of Jurkat cells. Chemistry & Physics of Lipids 180:53-60.

  • Loke WM, Chow AY, Lam KMS, Lee CYJ, Halliwell B, Lim ECH, Quek AML, Ooi EE, Seet RCS. (2013) Augmentation of 5-lipoxygenase activity and expression during dengue serotype-2 infection. Virology Journal 10:322-330.

  • Loke WM, Lam KMS, Lee CYJ, Chong WL, Chew SE, Huang H, Looi WF, Quek AML, Lim ECH, See RCS. (2013). Cycloxygenase-1 mediated platelet reactivity in young male smokers. Clinical & Applied Thrombosis/Hemostasis 20:371-377.

  • Chung MLS, Lee KYE, Lee CYJ*. (2013) Profiling of oxidized lipid products of marine fish under acute oxidative stress. Food & Chemical Toxicology 53:205-213.

  • Seet RCS. Lee CYJ, Lim ECH, Quek AML, Huang H, Huang SH, Looi WF, Long LH, Halliwell B. (2011) Oral zinc supplementation does not improve oxidative stress or vascular function in patients with type 2 diabetes with normal zinc levels. Atherosclerosis 219:231-239.

  • Seet RCS, Lee CYJ, Chan BPL, Sharma VK, Teoh HL, Venketasubramanian N, Lim ECH, Chong WL, Looi WF, Huang SH, Ong BKC, Halliwell B. (2011). Oxidative damage in ischemic stroke revealed using multiple biomarkers. Stroke 42:2326-2329.

  • Seet RCS, Lee CYJ, Loke WM, Huang SH, Huang H, Looi WF, Chew ES, Quek AML, Lim ECH, Halliwell B. (2011). Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? Free Radical Biology & Medicine 50:1787-1793.

* Corresponding Author(s) or Equal authorship

Year 2000-2010:

  • Halliwell B, Lee CYJ (2010). Isoprostanes as biomarkers of oxidative stress. Some rarely considered issues. Antioxidant & Redox Signaling. 13:145-156.

  • Seet RCS, Lee CYJ, Lim ECH, Quek AML, Huang SH, Khoo CM, Halliwell B. (2010). Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome. Diabetes Care 33:1140-1142.

  • Lim KHC, Lee CYJ, Earnest A, Seet RCS, Halliwell B. (2010). Studies on nasopharyngeal carcinoma patients; Are oxidative stress marker levels elevated in patients treated with concurrent chemotherapy and radiotherapy? Free Radical Research 44: 1064-1071.

  • Seet RCS, Lee CYJ, Lim ECH, Tan JJT, Quek AML, Chong WL, Looi WF, Huang SH, Chan YH, Halliwell B. (2010). Oxidative damage in Parkinsons disease. Measurement using accurate biomarkers.  Free Radical Biology & Medicine 48: 560-566.

  • Seet RCS, Lee CYJ, Lim ECH, Quek AML, Yeo LLL, Huang SH, Halliwell B. (2009). Oxidative damage in dengue fever. Free Radical Biology & Medicine 47: 375-380.

  • Gruber J, Tang SY, Jenner AM, Mudway I, Blomberg A, Behndig A, Kasiman K, Lee CYJ, Seet RCS, Zhang W, Chen C, Kelly F, Halliwell B (2009). Allantoin in human plasma, serum and nasal lining fluids as a biomarker of oxidative stress: avoiding artifacts and establishing real in vivo concentrations. Antioxidant & Redox Signaling 11:1767-1776.

  • Lee CYJ, Isaac HB, Huang SH, Long LH, Wang H, Gruber J, Ong CN, Kelly RP, Halliwell B. (2009). Limited antioxidant effect after consumption of a single dose of tomato sauce by young males, despite a rise in plasma lycopene. Free Radical Research 43:622-628.

  • Lee CYJ, Seet RCS, Huang SH, Long LH, Halliwell B. (2009). Different patterns of oxidized lipid products in plasma and urine of dengue fever, stroke and Parkinsons disease patients. Cautions in the use of biomarkers of oxidative stress, Antioxidant & Redox Signaling 11: 407-420.

  • Kelly RP, Yeo KP, Isaac HB, Lee CYJ, Huang SH, Teng L, Halliwell B, Wise SD. (2008). Lack of effect of acute oral ingestion o f vitamin C on oxidative stress, arterial stiffness or blood pressure in healthy subjects, Free Radical Research 42: 514-522.

  • Lee CYJ, Huang SH, Jenner AM, Halliwell B. (2008). Measurement of F2-isoprotsanes, hydroxyeicosatetraenoic products, oxysterols from a single plasma sample, Free Radical Biology & Medicine 44: 1314-1322.

  • Matayatsuk C, Lee CYJ, Kalprovidh RW, Sirankapracha P, Wilairat P, Fucharoen S, Halliwell B. (2007). Elevated F2-isoprostanes in thalassemic patients. Free Radical Biology & Medicine 43: 1649-1655.

  • Wang H, Jenner AM, Lee CYJ, Shui G, Tang SY, Whiteman M, Wenk MR, Halliwell B. (2007). The identification of antioxidants in dark soy sauce. Free Radical Research 41: 479-488.

  • Lee CYJ, Isaac HB, Wang H, Huang SH, Long LH, Jenner AM, Kelly RP, Halliwell B. (2006). Cautions in the use of biomarkers of oxidative damage; the vascular and antioxidant effects of dark soy sauce in humans. Biophysical & Biochemical Research Communications 344: 906-911.

  • Lee CYJ, Jenner AM, Halliwell B. (2004). Rapid preparation of human urine and plasma samples for analysis of F2-isoprostanes by gas chromatography-mass spectrometry. Biophysical & Biochemical Research Communications 320: 696-702.

  • Lee CYJ, Kim KC, Park HW, Song JH, Lee CH. (2004). Rheological properties of erythrocytes from male hypercholesterolemia. Microvascular Research 67: 133-138.

  • Rhee SJ, Lee CYJ, Kim MR, Lee CH. (2004). Potential antioxidant peptides in rice wine. Journal of Microbiology & Biotechnology 14: 715-721.

  • Rhee SJ, Lee CYJ, Kim KK, Lee CH. (2003). Comparison of the traditional (Samhaeju) and Industrial (Chongju) rice wine brewing in Korea. Food Science & Biotechnology 12: 242-247.

  • Cho CH, Hong YS, Kang K, Volkov VI, Skirda V, Lee CYJ, Lee CH. (2003). Water self-diffusion in Chlorella sp. studied by pulse field gradient NMR. Magnetic Resonance Imaging. 21: 1009-1017.

  • Suh KJ, Hong YS, Skirda VD, Volkov VI, Lee CYJ, Lee CH. (2003). Water self-diffusion behavior in yeast cells studied by pulsed field gradient NMR. Biophysical Chemistry 104: 121-130.

  • Lee CYJ, Kim MS, Yoon SW, Lee CH (2003). Short-term control of capsaicin on blood flow and oxidative stress of rats in vivo. Phytotherapy Research 17: 454-458.

  • Kang K, Lee CYJ, Lee CH (2002). Comparison of rheological properties of powder Chlorella sp. cultivated in fermentor and pond. Journal of Microbiology & Biotechnology 12: 740-745.

  • Yoon SW, Lee CYJ, Kim KM, Lee CH (2002). Leakage of cellular materials of yeast (saccharomyces cerevisiae) by ohmic heating. Journal of Microbiology and Biotechnology 12:183-188.

  • Lee CYJ, Wan JMF (2002). Immunoregulatory and antioxidant performance of alpha-tocopherol and selenium on human lymphocytes. Biological Trace Element Research 86:123-136.

  • Lee CYJ, Wan JMF (2000). Vitamin E supplementation improves cell-mediated immunity and oxidative stress of Asian men and women. Journal of Nutrition 130:2932-2937.


Current Postgraduate Students:


Sam Leung


Andy Leung


Harry Yau


Current Postgraduates (Co-Supervision):

Tai Hun Kim
Emily Kwun Kwan Lo
Vivian Wing Lam Poon
Duan Xinxing
Zuzanna Ostrowska

 

Graduates:

Yiu Yiu Lee (Ph.D.)
Dalal Samir AlGhawas (Ph.D.; Co-Supervise)
Sirius Chung (M.Phil.)

 

Current undergraduate project students:

Kevin Kai Man Cheng
Ismaiah Marsena Jasiel

 

Past undergraduate final year project students:

Harry Yu Fung Yau
Andy Ho Hang Leung
Hok Fung Chan (HKU Fellowship)
Joan Chung Yan Lee
Sam Kin Sum Leung