The Yan lab studies one of the fundamental questions in microbiology: how bacteria adapt to the various environmental stresses in their ecological niches, animal host, as well as clinical settings with the presence of antimicrobial agents. We currently focus on the mechanisms for enteric bacteria to adapt to the oxygen (O₂) deprived environment and O₂ deprivation coupled with various of other stresses, such as nutrient starvation, presence of antibiotics etc. We aim to uncover the detailed signal transduction systems involved in these processes and their physiological significance, and exploit the knowledge in translational research. We tackle these important and fundamental questions at the level of gene expression, coupled with approaches from biochemistry, chemistry, structure and bioinformatics.

 

The Yan lab, 2019

We always welcome the bright minds to join us. Together, we pursue excellence in academics and your own dreams.