Journal articles (*, corresponding author):

2012

  1. To SK, Zeng JZ, and Wong AS* (2012) Nur77: a potential therapeutic target in cancer. Expert Opin. Ther. Targets (in press).

2011

  1. Leung KW, Ng HM, Tang MK, Wong CK, Wong RN, and Wong AS* (2011) Ginsenoside-Rg1 mediates a hypoxia-independent upregulation of hypoxia-inducible factor-1a to promote angiogenesis. Angiogenesis 14: 515-522. Abstract

  2. Leung WK, Ching AK, Chan AW, Poon TC, Mian H, Wong AS, To KF, and Wong N (2011) A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility. Oncogene 30: 4464-4475. Abstract

  3. Cheung LW, Mak AS, Cheung AN, Ngan HY, Leung PC, and Wong AS* (2011) P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin. Oncogene 30: 2964-2974. Abstract

  4. Ip CK, Cheung AN, Ngan HY, and Wong AS* (2011) p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells. Oncogene 30: 2420-2432.Abstract

  5. Cheung LW, Leung KW, Wong CK, Wong RN, and Wong AS* (2011) Ginsenoside-Rg1 induces angiogenesis via non-genomic cross-talk of glucocorticoid receptor and fibroblast growth factor receptor-1. Cardiovasc. Res. 89: 419-425. Abstract

  6. Wu H, Lin Y, Li W, Sun Z, Gao W, Zhang H, Xie L, Jiang F, Qin B, Yan T, Chen L, Zhao Y, Cao X, Wu Y, Lin B, Zhou H, Wong AS, Zhang XK, and Zeng JZ (2011) Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells. FASEB J. 25: 192-205. Abstract

2010

  1. Leung KW, and Wong AS (2010) Pharmacology of ginsenosides: a literature review. Chin. Med. 5: 20. Abstract

  2. Cheung LW, Leung PC and Wong AS* (2010) Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer. Oncogene 29: 2427-2440. Abstract

  3. Tang MK, Zhou HY, Yam JW and Wong AS* (2010) c-Met overexpression contributes to the acquired apoptotic resistance of ovarian cancer cells through a cross-talk mediated by phosphatidylinositol 3-kinase and extracellular-signal regulated kinase 1/2. Neoplasia 12: 128-138 (Highlighted paper). Abstract

  4. Wong AS* (2010) An experimental model of ovarian carcinoma – more than just genetics. Cell Cycle 9: 228-229. Abstract

  5. Ting CM, Lee YM, Wong CK, Wong AS, Lung HL, Lung ML, Lo KW, Wong RN, Mak NK (2010) 2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways. Biochem. Pharmacol. 79: 825-841. Abstract

  6. Ching WK, Li L, Tsing NK, Tai CW, Ng TW, Wong AS, and Cheng KW (2010) A weighted local least squares imputation method for missing value estimation in microarray gene expression data. Int. J. Data Min. Bioinform.4, 331-347. Abstract

  7. Lau MT, Wong AS and Leung PC. Gonadotropins induce tumor cell migration and invasion by increasing cyclooxygenases expression and prostaglandin E2 production in human ovarian cancer cells. Endocrinology 151: 2985-2993. Abstract

 

2009

  1. Ching WK, Zhang SQ, Jiao Y, Akutsu T, Tsing NK and Wong AS (2009) Optimal control policy for probabilistic Boolean networks with hard constraints. IET Systems Biology 3: 90-99. Abstract

 

2008

  1. Pon YL, Zhou HY, Cheung AN, Ngan HY and Wong AS* (2008) p70 S6 kinase promotes epithelial to mesenchymal transition through Snail induction in ovarian cancer cells. Cancer Res. 68: 6524-6532. Abstract

  2. Yeung BH, Kwan BW, He QY, Lee AS, Liu J and Wong AS* (2008) Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis. Oncogene 27: 6782-6789. Abstract

  3. Yeung BH, Wong KY, Lin MC, Wong CK, Mashima T, Tsuruo T and Wong AS* (2008) Chemosensitization by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2. Br. J. Cancer 99: 283-293. Abstract

  4. Zhou HY, Pon YL and Wong AS* (2008) HGF/MET signaling in ovarian cancer. Curr. Mol. Med. 8: 469-480. Abstract

  5. Cheung LW and Wong AS* (2008) GnRH receptor signaling in extrapituitary tissues. FEBS J. 275: 5479-5495. Abstract

  6. Zhou HY, Wan KF, Ip CK, Wong CK, Mak NK, Lo KW and Wong AS* (2008) Hepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK. FEBS Lett. 582: 3415-3422. Abstract

  7. Law AY, Lai KP, Ip CK, Wong AS, Wagner GF and Wong CK (2008) Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells. Exp. Cell Res. 314: 1823-1830. Abstract

  8. Park SH, Cheung LW, Wong AS and Leung PC (2008) Estrogen regulates Snail and Slug in the downregulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha. Mol. Endocrinol. 22: 2085-2098 (Highlighted paper). Abstract

 

2007

  1. Cheung LW, Lee YF, Ng TW, Ching WK, Khoo US, Ng MK and Wong AS* (2007) CpG/CpNpG sites in the coding region are preferred sites for mutagenesis in the breast cancer susceptibility genes. FEBS Lett. 581: 4668-4674. Abstract

  2. Zhou HY, Pon YL and Wong AS*(2007) Synergistic effects of epidermal growth factor and hepatocyte growth factor on human ovarian cancer cell invasion and migration: role of ERK1/2 and p38 MAPK. Endocrinology 148: 5195-5208. Abstract

  3. Choi JH, Wong AS, Huang HF and Leung PC (2007) Gonadotropins and ovarian cancer. Endocr. Rev. 28: 440-461. Abstract

  4. Chen CL, Cheung LW, Lau MT, Choi JH, Auersperg N, Wang HS, Wong AS and Leung PC (2007) Differential role of gonadotropin-releasing hormone on human ovarian epithelial cancer cell invasion. Endocrine 31: 311-320. Abstract

  5.  Leung KW, Cheung LW, Pon YL, Wong RN, Mak NK, Fan TP, Au SC, Tombran-Tink J and Wong AS* (2007) Ginsenoside-Rb1 inhibits angiogenesis by regulating pigment epithelium-derived factor through estrogen receptor beta in human endothelial cells. Br. J. Pharmacol. 152: 207-215 (Special Commentary). Abstract

  6. Wong AS* and Leung PC (2007) Role of endocrine and growth factors on the ovarian surface epithelium. J. Obstet. Gynaecol. Res. 33: 3-16. Abstract

 

2006

  1. Pon YL and Wong AS* (2006) Gonadotropin-induced apoptosis in human ovarian surface epithelial cells is associated with cyclooxygenase-2 upregulation via the β-catenin/T cell factor signaling pathway. Mol. Endocrinol.20: 3336-3350. Abstract

  2. Leung KW, Pon YL, Wong RN and Wong AS* (2006) Ginsenoside-Rg1 induces vascular endothelial growth factor expression through glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and β-catenin/TCF dependent pathway in human endothelial cells.J. Biol. Chem. 281: 36280-36288. Abstract

  3. Cheung LW, Au SC, Cheung AN, Ngan HY, Tombran-Tink J, Auersperg N and Wong AS* (2006) Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells. Endocrinology 147:4179-4191. Abstract

  4. Cheung LW, Leung PC and Wong AS* (2006) Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun N-terminal kinase-mediated activation of matrix metalloproteinase-2 and -9. Cancer Res. 66: 10902-10910. Abstract

  5. Zhou HY and Wong AS* (2006) Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells. Endocrinology 147: 2557-2566. Abstract

 

2005

  1. He QY, Zhou Y, Wong E, Ehlen TG, Auersperg N, Chiu JF and Wong AS* (2005) Proteomic analysis of a preneoplastic phenotype in ovarian surface epithelial cells derived from prophylactic oophorectomies. Gynecol. Oncol.98: 68-76. Abstract

  2. Pon YL, Auersperg N and Wong AS* (2005) Gonadotropins regulate N-cadherin-mediated human ovarian surface epithelial cell survival at both post-translational and transcriptional levels through a cyclic AMP/protein kinase A pathway. J. Biol. Chem. 280: 15438-15448. Abstract

 

2004

  1. Wong AS, Roskelley CD, Pelech S, Miller D, Leung PC and Auersperg N (2004) Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation. Exp. Cell Res. 299: 248-256 (Highlighted paper). Abstract

  2. Maines-Bandiera SL, Huntsman D, Lestou VS, Kuo W-L, Leung PC, Horsman RD, Wong AS, Woo MMM, Choi KKC, Roskelley CD and Auersperg N (2004) Epithelio-mesenchymal transition in a neoplastic ovarian epithelial hybrid cell line. Differentiation 72: 150-161. (2004). Abstract

 

2003

  1. Wong AS* and Auersperg N (2003) Ovarian surface epithelium: family history and early events in ovarian cancer. Reprod. Biol. Endocrinol. 1: 70-77. Abstract

  2. Wong AS and Gumbiner BM (2003) Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin. J. Cell Biol.161: 1191-1203 (Highlighted paper). Abstract

 

Before joining HKU:

  1. Wong AS, Pelech SL, Woo MM, Yim G, Rosen B, Ehlen T, Leung PC and Auersperg N (2001) Coexpression of hepatocyte growth factor-Met: as an early step in ovarian carcinogenesis? Oncogene 20: 1318-1328. Abstract

  2. Auersperg N, Wong AS, Choi KC, Kang SK and Leung PC (2001) Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr. Rev. 22: 255-288. Abstract

  3. Wong AS, Kim SO, Leung PC, Auersperg N and Pelech SL (2001) Profiling of protein kinases in the neoplastic transformation of human ovarian surface epithelium. Gynecol. Oncol. 82: 305-311. Abstract

  4. Wong AS, Lui WY, Hui IT and Lee WM (2001) Rabbit SHBG: biosynthesis in the liver and testis during postnatal development and structural characterization by truncated proteins. Int. J. Androl. 24: 165-174. Abstract

  5. Wong AS, Leung PC and Auersperg N (2000) Hepatocyte growth factor promotes in vitro scattering and morphogenesis of human cervical carcinoma cells. Gynecol. Oncol. 78: 158-165. Abstract

  6. Wong AS, Maines-Bandiera SL, Roskelley CD, Rosen B, Wheelock MJ, Johnson KR, Leung PC and Auersperg N (1999) Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: Influence of family histories of ovarian cancer. Int. J. Cancer 81: 180-188. Abstract

  7. Wong AS, Maines-Bandiera SL, Leung PC and Auersperg N (1998) Metaplastic changes in cultured ovarian surface epithelium. In Vitro Cell. Dev. Biol.34: 668-670 (Cover story). Abstract

  8. Lee WM, Wong AS, Tu AWK, Cheung CH, Li JCH and Hammond GL (1997) Rabbit sex hormone binding globulin: primary structure, tissue expression, and structure/function analyses by expression in E. coli. J. Endocrinol. 153: 373-384. Abstract

 

Book Chapters:

  1. Cheung LW, Ip CK, and Wong AS*. Cadherin-catenin signaling in ovarian cancer progression. In: Cancer Metastasis - Biology & Treatment, Springer Life Sciences (in press).

  2. Yue PY, Cheng YK, Mak NK, Leung KW, Wong AS, Fan TP, and Wong RN (2007) Chapter 22 Ginseng and angiogenesis. In: Angiogenesis: Basic Science and Clinical Applications, M. E. Maragoudakis and E. Papadimitriou ed., Transworld Research Network Publisher, p.357-372.

  3. Wong AS and Auersperg N (2002) Normal ovarian surface epithelium. Cancer Treat. Res. 107: 161-183.